Dept of Clinical Neurosciences
University of Cambridge
Clifford Allbutt Building
Cambridge Biosciences Campus
Hills Road, CB2 0HA Cambridge (UK)
Tel: +44 1223 762042
email: spp24@cam.ac.uk
Stefano Pluchino, MD, PhD
Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy, and additional training at Cambridge University, UK. He is currently Professor of Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within the Department of Clinical Neurosciences at Cambridge University.
Stefano Pluchino has a strong interest in Regenerative Neuroimmunology, and his research over the last 20 years has recalibrated the classical view that cellular grafts only function through structural cell replacement and opened up a new therapeutic avenue by which to use exogenously delivered stem cells, or even stem cell-derived acellular therapies that include extracellular vesicles and exosomes.
The Pluchino team studies whether the accumulation of neurological disability observed in patients with chronic inflammatory neurological conditions can be slowed down using next generation molecular therapies. The overarching aim is to understand the basic mechanisms that allow exogenously delivered stem cells, gene therapy vectors and/or exosomes to create an environment that preserves damaged axons or prevents neurons from dying. Such mechanisms may be harnessed and used to modulate disease states in an effort to repair and/or regenerate critical components of the nervous system. By understanding the mechanisms of intercellular (stem cell) signalling, diseases of the central nervous system (CNS) may be treated more effectively, and significant neuroprotection may be achieved with new tailored molecular therapeutics.
His previous work has led to the first-in-kind clinical trials of allogeneic somatic neural stem cells in patients with progressive MS.
Stefano Pluchino is recipient of numerous national and international awards, among which the Italian Multiple Sclerosis Foundation (FISM) Rita Levi-Montalcini prize for outstanding research in MS (2007) and the International Royan Award for outstanding research in Stem Cell Biology and Technology (2010). He is a 2009 Italian Ministry of Health Young Investigator Awardee and 2010 European Research Council (ERC) Starting Independent Researcher.
His laboratory research on Regenerative Neuroimmunology is documented in >230 publications in international journals, including many recent articles in highly prestigious journals, such as Nature, Cell, Cell Stem Cell, Nat Cell Biol, Nat Chem Biol, PNAS, PLoS Med, Brain, Ann Neurol, and J Neurosci, as well as invited review articles in Nat Rev Neurosci, Physiol Reviews, Trends in Mol Med and Trends Immunol. His publications have to date received >14.000 citations (ISI-WOK), having a Hirsch Factor of 53.
email: spp24@cam.ac.uk
Tel.: +44 1223 331163 (office)
skype me at stefanopluchino
Twitter: @Pluchinolab
Senior staff/Post doctoral fellows
Luca Peruzzotti-Jametti, MD, PhD
Luca is a Clinical Research Associate and Honorary Clinical Fellow at the Department of Clinical Neurosciences, University of Cambridge (UK) and Neurology consultant.
His work has been focusing on the application of molecular and cellular therapies to acute and chronic disorders of the Central Nervous System (including ischemic stroke and multiple sclerosis).
After receiving his MD (2007) from the University Vita-Salute San Raffaele of Milan (Italy), Luca completed a residency program in Neurology at the same University in 2013.
He then successfully obtained a Wellcome Trust research training fellowship and completed a PhD in Clinical Neurosciences at the University of Cambridge (2018).
During the past years, he has worked as visiting scientist in major European universities, such as the University Hospital in Zürich (Switzerland), the University of Aarhus (Denmark), the Laboratory of Stem Cells and Restorative Neurology of Lund (Sweden) and the University of Innsbruck (Austria).
Currently, Luca is studying how progression works in multiple sclerosis by focusing on the link between immune cell metabolism and chronic neuroinflammation (thanks to a Fondazione Italiana Sclerosi Multipla-FISM Senior Research Fellowship).
email: lp429@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
skype me at lucaperuzzotti
Twitter: @Dr_LPJ
Alexandra Nicaise, PhD
Alexandra received her bachelors degree in Neuroscience from Trinity College, Hartford, CT, United States (2013). She then completed her PhD at the University of Connecticut Health Center in 2019 in the lab of Dr. Stephen Crocker. Her PhD thesis involved the characterization of neural progenitor cells developed from induced pluripotent stem cells from patients with primary progressive multiple sclerosis.
Alexandra joined the Pluchino Lab in March 2019 as a postdoctoral research associate to work on the development of induced neural stem cell therapeutics for progressive multiple sclerosis (PMS). In addition she is using induced neural stem cells from patients with PMS to model cellular senescence in vitro towards understanding why regeneration failure occurs in this disease.
Alex is recipient of an individual post-doctoral fellowship from the European Committee for Research and Treatment in MS (ECRIMS) (2021-2023) to study neural stem cell ageing in progressive MS.
email: an574@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
skype me at alexandramnicaise
Twitter: @Telencephale
Cory Willis, PhD
Cory received his bachelors degree in neuroscience from the University of Pittsburgh, Pittsburgh, PA, United States (2012). He then completed his PhD at the University of Connecticut in 2019 in the lab of Stephen Crocker. His PhD thesis was two-fold, first to characterize astrocyte-derived EVs as a means to identify and isolate astrocyte EVs from complex biological fluids and secondly to discern plasma EVs as immune regulators in an animal model of multiple sclerosis.
Cory joined the Pluchino Lab in May 2019 as a postdoctoral research associate to work on the characterization of the metabolic profile of induced microglia from progressive multiple sclerosis patients. In addition, he is contributing to an on-going project investigating how sustained mitochondrial activity in mononuclear phagocytes leads to a chronically active inflammatory phenotype in a pre-clinical animal model of progressive multiple sclerosis.
Cory is recipient of an individual post-doctoral fellowship from the National MS Society (NMSS, USA) (2021-2024) to study the role of succinate-Gpr91 signalling in astroglia.
email: cw739@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
skype me at cwillis53_1
Twitter: @exosomeguy
Graduate Students
Rosana-Bristena Ionescu, MD
Bristena received her Doctor of Medicine degree from “Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania) in 2020. Her senior project was in Dr. Ana-Maria Zagrean's lab in the Department of Physiology and Neuroscience, where she investigated the therapeutic potential of chloride transport modulation using in vitro models of stroke and excitotoxicity.
Bristena joined the Pluchino Lab in October 2020 as a PhD student with the support of the Medical Research Council Doctoral Training Partnership (MRC-DTP) and the Cambridge Trust to investigate the metabolic control of brain stem cell behaviour in ageing.
email: rbi24@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
skype me at bristena.ionescu
Monica Emili Garcia-Segura, BSc
Monica graduated in 2019 with High Distinction from the University of Toronto (Canada) with a Neuroscience Specialist degree. She then completed her MRes in Experimental Neuroscience with Distinction (ICL) inProfessor Jules Griffin´s lab, where she conducted a multi-omics study to map the metabolic consequences of Alzheimers Disease. Afterwards, she investigated the regional and cell-type distribution of somatic SNCA mutations in MSA post-mortem brain tissue with Professor Christos Proukakis at UCL.
Monica joined the lab in October 2021 as a PhD student with the support of the Medical Research Council Doctoral Training Partnership (MRC-DTP) and the School of Clinical Medicine Cambridge Trust Scholarship to investigate the role of extracellular metabolites in Progressive Multiple Sclerosis biological fluids and tissues.
email: me485@cam.ac.uk
Tel: +44 1223 331168 (office)
Fax: +44 1223 331174
Grzegorz Krzak, BSc, MSC
Greg received his Bachelor’s degree in neurobiology from Jagiellonian University, Cracow, Poland (2016). In 2016 he joined Prof. Miller’s lab to work on his MSc thesis in the department of Clinical Neuroscience at King’s College London. After graduation he joined Prof. Smith’s Lab at the Department of Neuroinflammation (UCL), Queen Square to study the role of hypoxia in multiple sclerosis.
Greg joined the PluchinoLab in October 2019 to work on his PhD thesis investigating the role of succinate receptor/GPR91 in immune cells during neuroinflammation.
email: gk433@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
skype me at krzak9327
Hebe Manos, BSc
Hebe completed her Bachelor’s degree in Biomedical Sciences at University College London (2021). She joined the Pluchino Lab in January 2023 as an MPhil student, investigating the metabolomic profile of microglial cells during early postnatal development and in adult pathological states. Her project aims to provide insight into the cellular and molecular mechanisms underlying neurodevelopmental and neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia.
Email: pp531@cam.ac.uk
Tel: +44 7747452096 (office)
Fax: +44 1223 331174
Skype me at pranathitp
Pranathi Prasad, BSc
Pranathi received her Bachelor’s degree in Biochemistry and Cell Biology from Jacobs University, Bremen, Germany (2021). She did her thesis project on Conformational Dynamics of MHC Class I Molecules with Professor Sebastian Springer at Jacobs University and her senior year project on Neuron-Glia Interactions in Peripheral Neuroinflammation at Charité’s Department of Microbiology, Infectious Diseases and Immunology (Berlin) with Dr. Christoph Klose.
Pranathi joined the Pluchino lab in October 2021 as a PhD student with the support of the Medical Research Council Doctoral Training Program (MRC-DTP) and the School of Clinical Medicine Cambridge International Scholarship. She will be investigating DNA damage-induced mechanisms of disease progression in age-related neurodegeneration with joint supervision from Dr Gabriel Balmus at the UK Dementia Research Institute.
Email: pp531@cam.ac.uk
Tel: +44 7747452096 (office)
Fax: +44 1223 331174
Skype me at pranathitp
Kassandra (Kay) Zhou, BSc
Kassandra completed her Bachelor’s Degree in Neuroscience and Physiology in 2022 at the University of British Columbia in Vancouver, Canada. During her undergraduate studies, she received supervised training on human brain dissection and neuroanatomy with Dr Wayne Vogl. In her senior year, Kassandra conducted a project to investigate Sertoli cell junction turnover, also with Dr Wayne Vogl in the Department of Cellular & Physiological Sciences.
Kassandra joined the Pluchino Lab in October 2022 as an MPhil student co-supervised with Irina Mohorianou (Wellcome-MRC Stem Cell Institute) with the goal of integrating expression data (proteins, metabolites, genes) with cellular behaviours. Her project will focus on the biology of disease pacemaker neural stem cells using single cell data analysis and machine learning.
Email: yz830@cam.ac.uk
Tel: +44 0789-588-5696
Skype me at live:kassandra.zhou
Undergraduate Students
Marlene Patterer, MSc
Marlene is currently completing her Bachelor’s degree in Biomedical Engineering at the University of Applied Sciences Technikum in Vienna, Austria.
Marlene joined the Pluchino Lab in February 2023 as a visiting research undergraduate student for finalising her Bachelor’s thesis under the supervision of Alexandra Nicaise and with the support of Erasmus for 6 months.
Her thesis project aims at providing new insights into the function and impact of exogenous (transplanted) disease-associated iNSCs on cerebral organoids, potentially promoting chronic inflammation and senescence, affecting the longevity of the organoid, and mimicking neurodegeneration and brain atrophy as seen in progressive MS patients.
Marlene will help characterize and understand the cell interactome in the ALICOs and aid in the generation of viruses and viral transductions.
email: mp2095@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
Laboratory Technicians
Alyson Speed, BSc
Alyson joined the University in 1992 in the Department of Pathology as a trainee technician. Moving around various departments gave exposure to various research programs gaining new skills with each group.
After a period away, in 2014 re-joined the University in the MRC-CU working with four Research groups (Ashok Ventikarman, Christian Frezza, Sakari Vanharata and Carla Martin). Working on lung, pancreatic, and metastases cancer projects.
Alyson Joined the Pluchino Lab in November 2022 as a Research Laboratory Technician.
email: ajs99@cam.ac.uk
Tel.: +44 1223 331168 (office)
fax: +44 1223 331174
Olena Hruba, MSc
Olena received her Bachelor’s degree in Biochemistry from the Ivan Franko National University of Lviv, Ukraine (2020). She then completed a Master's degree in Genetics and Biotechnology from the same University (2022).
Olena joined the PluchinoLab in November 2022 as a Research Laboratory Technician.
email: oh311@cam.ac.uk
Tel.: +44 7547905973 (office)