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Stefano Pluchino, MD, PhD

Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy, and additional training at Cambridge University, UK.  ​He is currently Professor of Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within the Department of Clinical Neurosciences at Cambridge University. 

Stefano Pluchino has a strong interest in Regenerative Neuroimmunology, and his research over the last 20 years has recalibrated the classical view that cellular grafts only function through structural cell replacement and opened up a new therapeutic avenue by which to use exogenously delivered stem cells, or even stem cell-derived acellular therapies that include extracellular vesicles and exosomes. 

The Pluchino team studies whether the accumulation of neurological disability observed in patients with chronic inflammatory neurological conditions can be slowed down using next generation molecular therapies. The overarching aim is to understand the basic mechanisms that allow exogenously delivered stem cells, gene therapy vectors and/or exosomes to create an environment that preserves damaged axons or prevents neurons from dying. Such mechanisms may be harnessed and used to modulate disease states in an effort to repair and/or regenerate critical components of the nervous system. By understanding the mechanisms of intercellular (stem cell) signalling, diseases of the central nervous system (CNS) may be treated more effectively, and significant neuroprotection may be achieved with new tailored molecular therapeutics.​

His previous work has led to the first-in-kind clinical trials of allogeneic somatic neural stem cells in patients with progressive MS.

Stefano Pluchino is recipient of numerous national and international awards, among which the Italian Multiple Sclerosis Foundation (FISM) Rita Levi-Montalcini prize for outstanding research in MS (2007) and the International Royan Award for outstanding research in Stem Cell Biology and Technology (2010). He is a 2009 Italian Ministry of Health Young Investigator Awardee and 2010 European Research Council (ERC) Starting Independent Researcher. 

 

His laboratory research on Regenerative Neuroimmunology is documented in >230 publications in international journals, including many recent articles in highly prestigious journals, such as Nature, Cell, Cell Stem Cell, Nat Cell Biol, Nat Chem Biol, PNAS, PLoS Med, Brain, Ann Neurol, and J Neurosci, as well as invited review articles in Nat Rev Neurosci, Physiol Reviews, Trends in Mol Med and Trends Immunol. His publications have to date received >14.000 citations (ISI-WOK), having a Hirsch Factor of 53.

 

email: spp24@cam.ac.uk

Tel.: +44 1223 331163 (office)

skype me at stefanopluchino

Twitter: @Pluchinolab

Senior staff/Post doctoral fellows

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Luca Peruzzotti-Jametti, MD, PhD

Luca is a Clinical Research Associate and Honorary Clinical Fellow at the Department of Clinical Neurosciences, University of Cambridge (UK) and Neurology consultant. 
His work has been focusing on the application of molecular and cellular therapies to acute and chronic disorders of the Central Nervous System (including ischemic stroke and multiple sclerosis).
After receiving his MD (2007) from the University Vita-Salute San Raffaele of Milan (Italy), Luca completed a residency program in Neurology at the same University in 2013. 
He then successfully obtained a Wellcome Trust research training fellowship and completed a PhD in Clinical Neurosciences at the University of Cambridge (2018). 
During the past years, he has worked as visiting scientist in major European universities, such as the University Hospital in Zürich (Switzerland), the University of Aarhus (Denmark), the Laboratory of Stem Cells and Restorative Neurology of Lund (Sweden) and the University of Innsbruck (Austria).
Currently, Luca is studying how progression works in multiple sclerosis by focusing on the link between immune cell metabolism and chronic neuroinflammation (thanks to a Fondazione Italiana Sclerosi Multipla-FISM Senior Research Fellowship).

email: lp429@cam.ac.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at lucaperuzzotti

Twitter: @Dr_LPJ

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Jayden Smith, PhD

Jayden received a BSc in Chemistry and Computer Science (2003) and a PhD in Inorganic Chemistry (2008) from James Cook University (Australia). His PhD thesis concerned the study of multinuclear metal complexes as stereoselective probes of nucleic acids.

He joined the PluchinoLab as a postdoctoral research associate in 2011. Here he worked on the development of RNA nanotherapeutics for combinatorial applications alongside induced neural stem cell transplantation for repair of the central nervous system.

He has since joined Cambridge Innovation Technologies Consulting Ltd as a Senior Research Associate and Project Manager. He has been recently appointed as Chief Scientific Officer (CSO) at asitia Therapeutics, a newly formed exosome biotech company, but remains with the PluchinoLab as a visiting researcher.

email: jayden.smith@citc-ltd.co.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at jayden.aaron.smith

Twitter: @GourmetJesus

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Alexandra Nicaise, PhD
Alexandra received her bachelors degree in Neuroscience from Trinity College, Hartford, CT, United States (2013). She then completed her PhD at the University of Connecticut Health Center in 2019 in the lab of Dr. Stephen Crocker. Her PhD thesis involved the characterization of neural progenitor cells developed from induced pluripotent stem cells from patients with primary progressive multiple sclerosis.

Alexandra joined the Pluchino Lab in March 2019 as a postdoctoral research associate to work on the development of induced neural stem cell therapeutics for progressive multiple sclerosis (PMS). In addition she is using induced neural stem cells from patients with PMS to model cellular senescence in vitro towards understanding why regeneration failure occurs in this disease. 

Alex is recipient of an individual post-doctoral fellowship from the European Committee for Research and Treatment in MS (ECRIMS) (2021-2023) to study neural stem cell ageing in progressive MS. 

email: an574@cam.ac.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at alexandramnicaise

Twitter: @Telencephale

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Cory Willis, PhD

Cory received his bachelors degree in neuroscience from the University of Pittsburgh, Pittsburgh, PA, United States (2012). He then completed his PhD at the University of Connecticut in 2019 in the lab of Stephen Crocker.  His PhD thesis was two-fold, first to characterize astrocyte-derived EVs as a means to identify and isolate astrocyte EVs from complex biological fluids and secondly to discern plasma EVs as immune regulators in an animal model of multiple sclerosis.

Cory joined the Pluchino Lab in May 2019 as a postdoctoral research associate to work on the characterization of the metabolic profile of induced microglia from progressive multiple sclerosis patients. In addition, he is contributing to an on-going project investigating how sustained mitochondrial activity in mononuclear phagocytes leads to a chronically active inflammatory phenotype in a pre-clinical animal model of progressive multiple sclerosis.

Cory is recipient of an individual post-doctoral fellowship from the National MS Society (NMSS, USA) (2021-2024) to study the role of succinate-Gpr91 signalling in astroglia. 

email: cw739@cam.ac.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at cwillis53_1

Twitter: @exosomeguy

Graduate Students

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Regan Hamel, BSc, MPhil

Regan graduated in 2017 from McGill University (Canada) with a Bachelors degree in Neuroscience and a focus on computation and physiology. Her senior project was in Dr. Mendola's lab in the department of Ophthalmology where she investigated the effect of individual differences on two visual phenomena: binocular rivalry and dichoptic masking. 

​Regan joined the PluchinoLab in October 2017 to work on her MPhil in Medical Sciences supported by a graduate scholarship from the Canadian Scholarship Trust Fund. After successfully completing her MPhil, and gaining the necessary wet lab and bioinformatic skills.

She continued on in the lab as PhD student with the support of a full scholarship (tuition and stipend) from the Cambridge Trust and a PhD project consumables grant from Rosetrees Trust. Regan’s PhD project involves the investigation of non-neuronal cells in the context of spinal cord injury using single cell RNA sequencing. 

 

email: rh680@cam.ac.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at regan_hamel

Twitter: @regan_hamel

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Rosana-Bristena Ionescu, MD

Bristena received her Doctor of Medicine degree from “Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania) in 2020. Her senior project was in Dr. Ana-Maria Zagrean's lab in the Department of Physiology and Neuroscience, where she investigated the therapeutic potential of chloride transport modulation using in vitro models of stroke and excitotoxicity.

Bristena joined the Pluchino Lab in October 2020 as a PhD student with the support of the Medical Research Council Doctoral Training Partnership (MRC-DTP) and the Cambridge Trust to investigate the metabolic control of brain stem cell behaviour in ageing.

 

email: rbi24@cam.ac.uk 

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at bristena.ionescu

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Monica Emili Garcia-Segura, BSc

Monica graduated in 2019 with High Distinction from the University of Toronto (Canada) with a Neuroscience Specialist degree. She then completed her MRes in Experimental Neuroscience with Distinction (ICL) inProfessor Jules Griffin´s lab, where she conducted a multi-omics study to map the metabolic consequences of Alzheimers Disease. Afterwards, she investigated the regional and cell-type distribution of somatic SNCA mutations in MSA post-mortem brain tissue with Professor Christos Proukakis at UCL. 

Monica joined the lab in October 2021 as a PhD student with the support of the Medical Research Council Doctoral Training Partnership (MRC-DTP) and the School of Clinical Medicine Cambridge Trust Scholarship to investigate the role of extracellular metabolites in Progressive Multiple Sclerosis biological fluids and tissues. 

 

email: me485@cam.ac.uk 

Tel: +44 1223 331168 (office)

Fax: +44 1223 331174 

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Grzegorz Krzak, BSc, MSC

Greg received his Bachelor’s degree in neurobiology from Jagiellonian University, Cracow, Poland (2016). In 2016 he joined Prof. Miller’s lab to work on his MSc thesis in the department of Clinical Neuroscience at King’s College London. After graduation he joined Prof. Smith’s Lab at the Department of Neuroinflammation (UCL), Queen Square to study the role of hypoxia in multiple sclerosis.

Greg joined the PluchinoLab in October 2019 to work on his PhD thesis investigating the role of succinate receptor/GPR91 in immune cells during neuroinflammation.

 

email: gk433@cam.ac.uk 

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at krzak9327

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Pranathi Prasad, BSc

Pranathi received her Bachelor’s degree in Biochemistry and Cell Biology from Jacobs University, Bremen, Germany (2021). She did her thesis project on Conformational Dynamics of MHC Class I Molecules with Professor Sebastian Springer at Jacobs University and her senior year project on Neuron-Glia Interactions in Peripheral Neuroinflammation at Charité’s Department of Microbiology, Infectious Diseases and Immunology (Berlin) with Dr. Christoph Klose. 

 

Pranathi joined the Pluchino lab in October 2021 as a PhD student with the support of the Medical Research Council Doctoral Training Program (MRC-DTP) and the School of Clinical Medicine Cambridge International Scholarship. She will be investigating DNA damage-induced mechanisms of disease progression in age-related neurodegeneration with joint supervision from Dr Gabriel Balmus at the UK Dementia Research Institute.

 

Email: pp531@cam.ac.uk
Tel: +44 7747452096 (office)
Fax: +44 1223 331174

Skype me at pranathitp

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Larissa Roth, BSc

Larissa completed her Bachelor´s Degree in Biomedicine in 2019 at the University of Würzburg (Julius-Maximilans-Universität Würzburg), where she is currently a Master´s Student of Biomedicine. During her Bachelor Traineeship she studied the effects of butyrophilins on Vgamma9Vdelta2 T-cell activation at the Institute of Immunology and Virology (Würzburg) with Professor Thomas Herrmann. 

Larissa joined the Pluchino Lab in March 2020, and then again in November 2021 under the sponsorship of an Erasmus+. She is working on a project aimed at characterising stem cell ageing in people with progressive MS.

 

email: lr521@cam.ac.uk 

Tel.: +44 1223 31168 (office)

fax: +44 1223 331174

Skype me at live:roth.larissa

Laboratory Technicians

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Vasiliki Pappa, BSc

Vasiliki received her BSc in Biology from University of Patras, Greece (2015). She then completed her MSc at Utrecht University, the Netherlands. During this period she joined dr. Caiazzo’s group (Utrecht University) working on a project regarding the generation of human astrocytes from human Embryonic Stem Cells (hESCs). Later she joined Prof. Martino’s group in San Raffaele Scientific Institute (Milan, Italy) working on a transplant strategy of Neural Precursor Cells (NPCs) to promote neuroprotection in multiple sclerosis.

Vasiliki joined the PluchinoLab in March 2020 to work as Junior Research Laboratory Technician.

email: vp399@cam.ac.uk

Tel.: +44 1223 331168 (office)

fax: +44 1223 331174

skype me at Vasiliki Pappa