Pluchino S, Smith JA. Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication. Cell 2019 Apr 4;177(2):225-227 (103. Pluchino and Smith. Cell 19.pdf)


Bernstock JD, Peruzzotti-Jametti L, Leonardi T, Vicario N, Ye D, Lee YJ, Maric D, Johnson KR, Mou Y, Van Den Bosch A, Winterbone M, Friedman GK, Franklin RJM, Hallenbeck JM, Pluchino S.SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke. EBioMedicine 2019 Apr;42:214-224 (102. Bernstock et al. EBiomedicine 19.pdf)




L Peruzzotti-Jametti and S Pluchino. Targeting mitochondrial metabolism in neuroinflammation: towards a therapy for progressive multiple sclerosis? Trends Mol Med 2018 Oct;24(10):838-855 (100. Peruzzotti-Jametti and Pluchino. TMM 18.pdf);


F L’Episcopo, L Peruzzotti-Jametti, MF Serapide, C Tirolo, N Testa, B Balzarotti, S Caniglia, S Pluchino, B Marchetti. Neural stem cell transplantation in aged Parkinsonian mice promotes neurorestoration via promotion of astrocyte-induced Wnt/inflammatory cascade. Stem Cells 2018 2018 Aug;36(8):1179-1197 (98. L'Episcopo et al. Stem Cells 18.pdf)


PP Amaral, T Leonardi, N Han1, E Viré, DK Gascoigne, R Arias-Carrasco, M Buscher, A Zhang, S Pluchino, V Maracaja-Coutinho, HI Nakaya, Martin Hemberg, R Shiekhattar, AJ Enright, T Kouzarides. Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci. Genome Biol 2018 Mar 15; 19(1): 32 (97. Amaral et al. Gen Biol 18.pdf)


JA Smith, A Braga, J Verheyen, S Basilico, C Alfaro-Cervello, L Peruzzotti-Jametti, F Haque, P Guo, S Pluchino. RNA nanotherapeutics for the amelioration of astroglial reactivity. Mol Ther Nucleic Acids2018 Mar 2; 10: 103-121;


E Mauri, A Sacchetti, N Vicario, L Peruzzotti-Jametti, F Rossi and S Pluchino. Hybrid hydrogel library as 3D neural stem cell culture systems. Biomater Sci 2018 Feb 27; 6(3): 501-510 (95. Mauri et al. Biomat Sci 18.pdf)


L Peruzzotti-Jametti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza and S Pluchino. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell 2018 Mar 1; 22(3): 355-368 (96. Peruzzotti-Jametti et al. Cell Stem Cell 18.pdf

* Preview Commentary by Z Kokaia and O Lindvall. Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation (Preview Kokaia and Lindvall.pdf)


Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W. Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. FASEB J 2018 Mar; 32(3): 1677-1691 (90. Bernstock et al. FASEB J 17.pdf)


F L'Episcopo, S Caniglia, C Tirolo, MF Serapide, N Testa, L Leggio, S Vivarelli, N Iraci, S Pluchino, B Marchetti. Microglia Polarization, Gene-Environment Interactions and Wnt/â-catenin Signalling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Parkinsonian Brain. Front Aging Neurosci 2018 Feb 12; 10:12 (99. L'Episcopo fnagi-10-00012.pdf)


M Donegà, E Giusto, T Leonardi, C Alfaro-Cervello and S Pluchino. Group I metabotropic glutamate receptor signalling regulates the release of BDNF and LIF by neural stem cells. Matters, DOI: 10.19185/matters.201801000002


JD Bernstock, W Yang, DG Ye, Y Shen, S Pluchino, Y Lee, JM Hallenbeck, W Paschen. SUMOylation in Brain Ischemia: Patterns, Targets, and Translational Implications. J Cereb Blood Flow Metab 2018 Jan;38(1):5-16 (91. Bernstock et al. JCBFM 17.pdf)


A Fuster-Matanzo, G Manferrari, B Marchetti and S Pluchino. Wnt3a promotes pro-angiogenic features in macrophages in vitro: implications for stroke pathology. Exp Biol Med (Maywood) 2018 Jan;243(1):22-2 (92. Fuster-Matanzo et al. Exp Biol Med 17.pdf)




Scolding NJ, Pasquini M, Reingold SC, Cohen JA on behalf of attendees at the International Conference on Cell-Based Therapies for Multiple Sclerosis. Cell-based therapeutic strategies for multiple sclerosis. Brain. 2017 Nov 1;140(11):2776-2796 (89. Scolding et al. Brain 17.pdf)


JD Bernstock, D Ye, FA Gessler, L Peruzzotti-Jametti, MR Gilbert, Y Pommier, S Pluchino, I Nakano, JM Hallenbeck. Topotecan Decreases the Expression of Programmed Death-Ligand 1 in Glioblastoma; Implications for Immunotherapy. Matters(https://www.sciencematters.io/articles/201709000008/info)


Huang B, Jiang XC, Zhang TY, Hu YL, Tabata Y, Chen Z, Pluchino S, Gao JQ. Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia. Int J Pharm 2017 Aug 18; 531(1):90-100 (86. Huang et al. Int J Pharmac 17.pdf)


N Iraci, E Gaude, T Leonardi, ASH Costa, C Cossetti, HK Saini, AJ Enright, C Frezza and S Pluchino. Extracellular vesicles are independent metabolic units delivering functional Asparaginase-like protein 1. Nat Chem Biol 2017 Sep;13(9):951-955 (83. Iraci et al. Nat Chem Biol 17.pdf). * News and Viewsby Lucas B Sullivan Taking Metabolism on the Road (nchembio.2455.pdf)


Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM. Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. Sci Rep 2017 Aug 7; 7(1):7425 (85. Bernstock et al. Sci Rep 17.pdf)


JD Bernstock, L Peruzzotti-Jametti, D Ye, FA Gessler, Y Lee, JM Hallenbeck and S Pluchino. Neural Stem Cell transplantation in Ischemic Stroke: a Role for Preconditioning and Cellular Engineering. J Cereb Blood Flow Metab 2017 Jul; 37(7):2314-2319 (80. Bernstock et al. JCBFM 17.pdf)


E Giusto, M Donegà, A Dumitru, G Foschi, M Bianchi, A Russo, S Casalini, T Leonardi, F Biscarini, R Garcia and S Pluchino. Interfacing Polymers and Tissues: Quantitative Local Assessment of the Foreign Body Reaction of Mononuclear Phagocytes to Polymeric Materials. Adv Biosys doi: 10.1002/adbi.201700021 (83. Giusto_et_al-2017-Advanced_Biosystems.pdf)


Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, Maji S, Monteleone F, Øverbye A, Panaretakis T, Patel T, Peinado H, Pluchino S, Principe S, Ronquist G, Royo F, Sahoo S, Spinelli C, Stensballe A, Théry C, van Herwijnen MJC, Wauben M, Welton JL, Zhao K, Mathivanan S. A novel community driven software for functional enrichment analysis of extracellular vesicles data. J Extracell Vesicles. 2017 May 26; 6(1):1321455 (84. Pathan  et al. J Extracell Vesicles 17.pdf)


Ballini A, Scacco S, Coletti D, Pluchino S, Tatullo M. Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine. Stem Cells Int 2017; 2017: 3292810 (82. Ballini et al. Stem Cells International 17.pdf)




Volpe G, Bernstock JD, Peruzzotti-Jametti L, Pluchino S. Modulation of host immune responses following non-hematopoietic stem cell transplantation: Translational implications in progressive multiple sclerosis. J Neuroimmunol. 2016 Dec 15. pii: S0165-5728(16)30312-5 (79. Volpe et al. J Neuroimmunol 17.pdf)


Pluchino S, Peruzzotti-Jametti L. Interleukin-4 induced 1 (IL4I1) promotes central nervous system remyelination. Brain. 2016 Dec;139(Pt 12):3052-3054 (78. Pluchino et al. Brain 16.pdf)


S Pluchino, L Peruzzotti-Jametti, C Frezza. Astrocyte power fuels neurons during stroke. Swiss Med Wkly. 2016;146:w14374 (77. Pluchino et al. Swiss Medical Weekly 16.pdf)


D Drago, V Basso, E Gaude, G Volpe, L Peruzzotti-Jametti, A Bachi, G Musco, A Andolfo, C Frezza, A Mondino and S Pluchino. Metabolic determinants of the immune modulatory function of neural stem cells. J Neuroinflammation 2016 Sep 2;13(1):232 (76. Drago et al. J Neuroinflamm 16.pdf)


N Gagliano, G Celesti, L Tacchini, S Pluchino, M Rasile, V Valerio, L Laghi, V Conte, P Procacci. Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma cells: characterization in a 3D-cell culture model. World J Gastroent 2016 May 14;22(18):4466-83 (75. Gagliano et al. WJG 16.pdf)


S Stewart, F Gessler, S Pluchino and K Moreau. Inside out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles. Matters (https://www.sciencematters.io/articles/201602000015)


B Ossola, C Zhao, M Goedert, A Compston, S Pluchino, RJM Franklin, MG Spillantini. Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation. Glia. 2016 Mar;64(3):457-71 (71. Ossola_et_al-Glia 15.pdf)


N Iraci, T Leonardi, F Gessler, B Vega and S Pluchino. Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles. Int J Mol Sci. 2016 Feb 6;17(2)*invited review article (74. Iraci et al. Int J Mol Sci 16.pdf)


JD Bernstock, Y Lee, L Peruzzotti-Jametti, N Southall, KR Johnson, D Maric, G Volpe, J Kouznetsova, W Zheng, S Pluchino, JM Hallenbeck. A Novel Quantitative High-throughput Screen Identifies Drugs that both Activate SUMO-conjugation via the Inhibition of MicroRNAs 182 and 183 and Facilitate Neuroprotection in a Model of Oxygen and Glucose Deprivation. J Cereb Blood Flow Metab. 2016 Feb;36(2):426-41 (70. Bernstock et al. JCBFM 16.pdf)




T Lener et al.  Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. Journal of Extracellular Vesicles 2015, 4: 30087 (73. Lener et al. JEV 15.pdf)


A Fuster-Matanzo, F Gessler, T Leonardi, N Iraci and S Pluchino. Acellular Approaches for Regenerative Medicine: on the Verge of Clinical Trials with Extracellular Membrane Vesicles? Stem Cell Res Ther 2015 Dec 2;6:227*invited review article (72. Fuster Matanzo et al. Stem Cell Res Ther 15.pdf)


S Tambalo, L Peruzzotti-Jametti, R Rigolio, S Fiorini, P Bontempi, G Mallucci, A Sbarbati, P Marmiroli, G Cavaletti, S Pluchino, P Marzola. Functional magnetic resonance imaging reveal brain cortex remodelling in a rat model of chronic multiple sclerosis. J Neurosci 2015 July 8;35(27): 10088 –10100 (69. Tambalo et al. J Neurosci 15.pdf)


Smith JA, Leonardi T, Huang B, Iraci N, Vega B, Pluchino S. Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases. Biogerontology. 2015 Apr;16(2):147-85 (63. Smith et al. Biogerontology 14.pdf)


Mallucci G, Peruzzotti-Jametti L, Bernstock JD, Pluchino S. The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis. Prog Neurobiol 2015 Apr;127-128C:1-22 (67. Mallucci et al. Progr Neurobiol 15.pdf)


GM Tannahill, N Iraci, E Gaude, C Frezza and S Pluchino. Metabolic reprogramming of mononuclear phagocytes and progressive multiple sclerosis. Front Immunol 2015 Mar 11;6:106 (66. Tannahill et al. Front Immunol 15.pdf)




Giusto E, Donegà M, Cossetti C and Pluchino S. Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. Exp Neurol 2014 Oct;260C:19-32 (54. Giusto, Donegà et al. Exp Neurol 13.pdf)


C Cossetti, N Iraci, TR Mercer, T Leonardi, E Alpi, D Drago, C Alfaro-Cervello, H Saini, M Davis, J Schaeffer, W Muller, JM Garcia-Verdugo, S Mathivanan, A Bachi, A Enright, JS Mattick, S Pluchino. Extracellular vesicles from neural stem cells transfer IFN- via Ifngr1 to activate Stat1 signalling in target cells. Mol Cell 2014 Oct 23;56(2):193-204 (64. Cossetti Iraci et al. Mol Cell 14.pdf)


DM Hermann, L Peruzzotti-Jametti, J Schlechter, JD Bernstock, TR Doeppner, S Pluchino. Neural precursor cells in the ischemic brain - integration, cellular crosstalk and consequences for stroke recovery. Front Cell Neurosci 2014 Sep 16;8:291 (65. Hermann et al. Front Cell Neurosci 14.pdf)


L Peruzzotti-Jametti, M Donegá, E Giusto, G Mallucci, B Marchetti, S Pluchino. The role of immune system in central nervous system plasticity after acute injuries. Neuroscience 2014 Apr 29. pii: S0306-4522(14)00339-X (62. Peruzzotti-Jametti et al. Neuroscience 14.pdf)


M Donegà, E Giusto, C Cossetti, J Schaeffer and S Pluchino. Systemic injection of neural stem/progenitor cells in mice with chronic EAE.  J Vis Exp 2014 Apr 15;(86) (59. Donega et al. JoVE 14.pdf)


F L’Episcopo, C Tirolo, N Testa, S Caniglia, MC Morale, MF Serapide, S Pluchino, B Marchetti. Wnt/â-catenin signalling is required to rescue midbrain dopaminergic progenitors and restore nigrostriatal plasticity in ageing mouse model of Parkinson’s disease.  Stem Cells 2014 Aug;32(8):2147-63 (61. L'Episcopo et al. Stem Cells 14.pdf)


Cerri F, Salvatore L, Memon D, Martinelli Boneschi F, Madaghiele M, Brambilla P, Del Carro U, Taveggia C, Riva N, Trimarco A, Lopez ID, Comi G, Pluchino S, Martino G, Sannino A, Quattrini A. Peripheral nerve morphogenesis induced by scaffold micropatterning. Biomaterials 2014; 35: 4035-45 (60. Cerri et al. Biomaterials 14.pdf)


F L’Episcopo, C Tirolo, S Caniglia, N Testa, MC Morale, MF Serapide, S Pluchino, B Marchetti. Targeting Wnt signaling at the neuroimmune interface in dopaminergic neuroreprotection/repair in Parkinson’s disease. J Mol Cell Biol 2014; 6: 13-26 (61. L'Episcopo et al. J Mol Cell Biol 14.pdf)




AF Hill, DM Pegtel, U Lambertz, T Leonardi, L O’Driscoll, S Pluchino, D Ter-Ovanesyan, ENM Nolte-‘t Hoen. ISEV Position Paper: Extracellular Vesicle RNA analysis and bioinformatics. J Extracell Vesicles2013 Dec 23 (57. Hill et al. J Extracell Vesicles 13.pdf)


S Pluchino and L Peruzzotti-Jametti. Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons Brain 2013, 136: 3525-3527 (58. Pluchino and Peruzzotti. Brain 13.pdf)


D Drago, C Cossetti, N Iraci, E Gaude, G Musco, A Bachi and S Pluchino. The stem cell secretome and its role in brain repair. BIOCHIMIE. 2013 Dec;95(12):2271-85 (56. Drago et al. BIOCHIMIE 13.pdf)


Pluchino S and Cossetti C. How stem cells speak with host immune cells in inflammatory brain diseases. GLIA 2013 Sep;61(9):1379-401 (55. Pluchino and Cossetti. GLIA 13.pdf)


Marchetti B, L’Episcopo F, Morale MC, Tirolo C, Testa N, Caniglia S, Serapide MF and Pluchino S. Uncovering Novel Actors in Astrocyte-Neuron Crosstalk in Parkinson’s Disease: the Wnt/â-Catenin Signaling Cascade as Common Final Pathway for Neuroprotection and Self-Repair. Eur J Neurosci2013 May; 37(10):1550-63 (53. Marchetti et al. Eur J Neurosci 13.pdf)


L'episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Impagnatiello F, Pluchino S, Marchetti B. Aging-Induced Nrf2-ARE Pathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice via PI3K-Wnt/â-Catenin Dysregulation. J Neurosci 2013 Jan 23;33(4):1462-148 (52. L'Espiscopo et al. J Neurosci 13.pdf)


Marchetti B, Pluchino S. Wnt your brain be inflamed? Yes, it Wnt! Trends Mol Med 2013 Mar;19(3):144-56 (51. Marchetti and Pluchino. Trends Mol Med 13.pdf




Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012 Dec;10(12):e1001450. doi: 10.1371/journal.pbio.1001450 (50. Kalra et al. PLoS Biol 12.pdf)


Cossetti C, Alfaro-Cervello C, Donegà M, Tyzack G, Pluchino S. New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies. Cell Tissue Res. 2012 Jul;349(1):321-9. doi: 10.1007/s00441-012-1341-8 (48. Cossetti et al. Cell Tissue Res 12.pdf)


Herz J, Reitmeir R, Hagen SI, Reinboth BS, Guo Z, Zechariah A, ElAli A, Doeppner TR, Bacigaluppi M, Pluchino S, Kilic U, Kilic E, Hermann DM. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions. Neurobiol Dis. 2012 Mar;45(3):1077-85. doi: 10.1016/j.nbd.2011.12.026 (44. Herz et al. Neurobiol Disease 11.pdf


L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Deleidi M, Serapide MF, Pluchino S, Marchetti B. Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/â-catenin signaling pathways: functional consequences for neuroprotection and repair. J Neurosci. 2012 Feb 8;32(6):2062-85. doi: 10.1523/JNEUROSCI.5259- (47. L'Espiscopo et al. J Neurosci 12.pdf)


Cusimano M, Biziato D, Brambilla E, Donegà M, Alfaro-Cervello C, Snider S, Salani G, Pucci F, Comi G, Garcia-Verdugo JM, De Palma M, Martino G, Pluchino S. Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain. 2012 Feb;135(Pt 2):447-60. doi: 10.1093/brain/awr339 (46. Cusimano et al. Brain 12.pdf)


Cossetti C, Smith JA, Iraci N, Leonardi T, Alfaro-Cervello C, Pluchino S. Extracellular membrane vesicles and immune regulation in the brain. Front Physiol. 2012;3:117. doi: 10.3389/fphys.2012.00117 (49. Cossetti et al. Front Phys 12.pdf)




Pluchino S, Alfaro-Cervello C. Cyclooxygenase (COX)-1 takes control of adult hippocampal neurogenesis. Cell Cycle. 2011 Oct 1;10(19):3229. doi: 10.4161/cc.10.19.17079 (42. Pluchino and Alfaro-Cervello Cell Cycle 11.pdf)


Martino G, Pluchino S, Bonfanti L, Schwartz M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev. 2011 Oct;91(4):1281-304. doi: 10.1152/physrev.00032.2010 (41. Martino et al. Phys Rev 11.pdf)


L'episcopo F, Serapide MF, Tirolo C, Testa N, Caniglia S, Morale MC, Pluchino S, Marchetti B. A Wnt1 regulated Frizzled-1/â-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener. 2011 Jul 13;6:49. doi: 10.1186/1750-1326-6-49 (40. L'Episcopo et al. Mol Neurod 11.pdf)


Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV. Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell Stem Cell. 2011 May 6;8(5):538-51. doi: 10.1016/j.stem.2011.03.011 (39. Cimadamore et al. Cell Stem Cell 11.pdf)


L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E, Andreoni L, Ihekwaba AE, Serra PA, Franciotta D, Martino G, Pluchino S, Marchetti B. Reactive astrocytes and Wnt/â-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis. 2011 Feb;41(2):508-27. doi: 10.1016/j.nbd.2010.10.023 (37. L'Episcopo et al. Neurobiol Disease 11.pdf)


Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S, Gassmann M, Hermann DM. Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain. 2011 Jan;134(Pt 1):84-99. doi: 10.1093/brain/awq344 (38. Reitmer et al. Brain 11.pdf)




Pluchino S, Cusimano M, Bacigaluppi M, Martino G. Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches. Arch Ital Biol. 2010 Jun;148(2):173-83 (36. Pluchino et al. Arch Ital Biol 10.pdf)


Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V, Bosi E, Martino G, Bonifacio E, Doglioni C, Piemonti L. Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice. PLoS One. 2010 Apr 27;5(4):e10357. doi: 10.1371/journal.pone.0010357 (35. Melzi et al. PLoS One 10.pdf)


Freedman MS, Bar-Or A, Atkins HL, Karussis D, Frassoni F, Lazarus H, Scolding N, Slavin S, Le Blanc K, Uccelli A; MSCT Study Group. The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group. Mult Scler. 2010 Apr;16(4):503-10. doi: 10.1177/1352458509359727 (33. Freedman et al. Multiple Sclerosis 10.pdf)




Gagliano N, Costa F, Cossetti C, Pettinari L, Bassi R, Chiriva-Internati M, Cobos E, Gioia M, Pluchino S. Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model. Oncol Rep. 2009 Dec;22(6):1349-56 (31 Gagliano et al. Oncology Reports 09.pdf)


Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, 't Hart B, Vescovi A, Martino G. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol. 2009 Sep;66(3):343-54. doi: 10.1002/ana.21745 (32 Pluchino and Gritti Ann Neurol 09.pdf)


Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ, Comi G, Martino G, Hermann DM. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009 Aug;132(Pt 8):2239-51. doi: 10.1093/brain/awp174 (29 Bacigaluppi et al. Brain 09.pdf)


Shechter R, London A, Varol C, Raposo C, Cusimano M, Yovel G, Rolls A, Mack M, Pluchino S, Martino G, Jung S, Schwartz M. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med. 2009 Jul;6(7):e1000113. doi: 10.1371/journal.pmed.1000113 (30 Shechter et al PLoS Med 09.pdf)


Pluchino S, Zanotti L, Brambilla E, Rovere-Querini P, Capobianco A, Alfaro-Cervello C, Salani G, Cossetti C, Borsellino G, Battistini L, Ponzoni M, Doglioni C, Garcia-Verdugo JM, Comi G, Manfredi AA, Martino G. Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One. 2009 Jun 19;4(6):e5959. doi: 10.1371/journal.pone.0005959 (28 Pluchino et al. PLoS One 09.pdf)


Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G. Regeneration and repair in multiple sclerosis: the role of cell transplantation. Neurosci Lett. 2009 Jun 12;456(3):101-6. doi: 10.1016/j.neulet.2008.03.097 (27 Pluchino et al. Neurosci Letters 09.pdf)




Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E, Cavasinni F, Bergamaschi A, Garcia-Verdugo JM, Comi G, Khoury SJ, Martino G. Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain. 2008 Oct;131(Pt 10):2564-78. doi: 10.1093/brain/awn198 (24 Pluchino et al. Brain 08.pdf)


Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Esposito M, Stornaiuolo A, Comi G, Pluchino S, Mavilio F, Martino G, Furlan R. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther. 2008 Apr;15(7):504-15. doi: 10.1038/gt.2008.10 (23 Butti et al. Gene Ther 08.PDF)


Pluchino S, Martino G. Neural stem cell-mediated immunomodulation: repairing the haemorrhagic brain. Brain. 2008 Mar;131(Pt 3):604-5. doi: 10.1093/brain/awn015 (22 Pluchino and Martino. Brain 08.pdf)


Pluchino S, Martino G. The therapeutic plasticity of neural stem/precursor cells in multiple sclerosis. J Neurol Sci. 2008 Feb 15;265(1-2):105-10 (21 Pluchino and Martino J Neurol Sci 08.pdf)


Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann DM. Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci. 2008 Feb 15;265(1-2):73-7 (20 Bacigaluppi et al. J Neurol Sci 08.pdf)


Serra PA, Pluchino S, Marchetti B, Desole MS, Miele E. The MPTP mouse model: cues on DA release and neural stem cell restorative role. Parkinsonism Relat Disord. 2008;14 Suppl 2:S189-93. doi: 10.1016/j.parkreldis.2008.04.029 (26 Serra et al. Parkinsonism Relat Disord 08.pdf)




Politi LS, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, Comi G, Scotti G, Martino G, Pluchino S. Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells. 2007 Oct;25(10):2583-92 (18 Politi et al. Stem Cells 07.pdf)


Martino G, Pluchino S. Neural stem cells: guardians of the brain. Nat Cell Biol. 2007 Sep;9(9):1031-4 (19 Martino and Pluchino. Nat Cell Biol 07.pdf)




Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13174-9 (16 Ziv et al. PNAS 06.pdf)


Martino G, Pluchino S. The therapeutic potential of neural stem cells. Nat Rev Neurosci. 2006 May;7(5):395-406 (15 Martino and Pluchino. Nat Rev Neurosci 06.pdf)


Amadio S, Pluchino S, Brini E, Morana P, Guerriero R, Martinelli Boneschi F, Comi G, Zaratin P, Muzio V, del Carro U. Motor evoked potentials in a mouse model of chronic multiple sclerosis. Muscle Nerve. 2006 Feb;33(2):265-73 (13 Amadio et al. Muscle and Nerve 06.pdf)


Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006 Jan;31(1):149-60 (12 Butovsky et al. Mol Cell Neurosci 06.pdf)




Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature. 2005 Jul 14;436(7048):266-71 (11 Pluchino et al. Nature 05.pdf)


Pluchino S, Martino G. The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci. 2005 Jun 15;233(1-2):117-9 (10 Pluchino et al. J Neurol Sci 05.pdf)


Pluchino S, Zanotti L, Deleidi M, Martino G. Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev. 2005 Apr;48(2):211-9 (9 Pluchino et al. Brain Res Rev 05.pdf)


Pluchino S, Bacigaluppi M, Bucello S, Butti E, Deleidi M, Zanotti L, Martino G, Furlan R. Gene and stem cell therapy for autoimmune demyelination. Ernst Schering Res Found Workshop. 2005;(53):133-46 (14 Pluchino et al. Ernst Schering Res Found 05.pdf)




Furlan R, Butti E, Pluchino S, Martino G. Gene therapy for autoimmune diseases. Curr Opin Mol Ther. 2004 Oct;6(5):525-36


Pluchino S, Furlan R, Martino G. Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies. Curr Opin Neurol. 2004 Jun;17(3):247-55 (8 Pluchino et al. Curr Opin Neurol 04.pdf)




Pluchino S, Zanotti L, Martino G. Antibodies and myelination: facts and misacts. Neurol Sci. 2003 Oct;24 Suppl 4:S231-3 (6 Pluchino et al. Neurol Sci 03.pdf)


Furlan R, Pluchino S, Martino G. The therapeutic use of gene therapy in inflammatory demyelinating diseases of the central nervous system. Curr Opin Neurol. 2003 Jun;16(3):385-92 (4 Furlan et al. Curr Opin Neurol 03.pdf)


Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003 Apr 17;422(6933):688-94 (7 Pluchino et al. Nature 03.pdf) *News and Views by L Steinman Collateral damage repaired (422671a.pdf)


Furlan R, Brambilla E, Sanvito F, Roccatagliata L, Olivieri S, Bergami A, Pluchino S, Uccelli A, Comi G, Martino G. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain. 2003 Feb;126(Pt 2):285-91 (2 Furlan et al. Brain 03.pdf)


Furlan R, Pluchino S, Martino G. Gene therapy-mediated modulation of immune processes in the central nervous system. Curr Pharm Des. 2003;9(24):2002-8 (5 Furlan et al. Curr Pharma Des 03.pdf)


Furlan R, Pluchino S, Marconi PC, Martino G. Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectors. Methods Mol Biol. 2003;215:279-89 (1 Furlan et al. MMB03.pdf)




Annunziata P, Pluchino S, Martino T, Guazzi G. High levels of cerebrospinal fluid IgM binding to myelin basic protein are associated with early benign course in multiple sclerosis. J Neuroimmunol. 1997 Jul;77(1):128-33

Pluchino Lab

Regenerative Neuroimmunology

University of Cambridge Bioscience Campus

Department of Clinical Neurosciences

Clifford Albutt Building

Hills Road

Cambridge, CB2 0AH (UK)

Tel: +44 1223 762042



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