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R Hamel, L Peruzzotti-Jametti, K Ridley, V Testa, B Yu, D Rowitch, J Marioni and S Pluchino. Time-resolved single-cell RNAseq profiling identifies a novel Fabp5-expressing subpopulation of inflammatory myeloid cells in chronic spinal cord injury. bioRxiv,doi.org/10.1101/2020.10.21.346635

X Yao, J Chen, Z Yu, Z Huang, R Hamel, Y Zeng, Z Huang, K Tu, J Liu, Y Lu, Z Zhou, , Q Zhu, J Chen. Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. Front Immunol, 2022 Aug 24;13:964138;

L Leggio, F L’Episcopo, A Magrì, MJ Ulloa-Navas, G Paternò, S Vivarelli, C Bastos, C Tirolo, N Testa, S Caniglia, P Risiglione, F Pappalardo, N Faria, L Peruzzotti-Jametti, S Pluchino, JM Garcia-Verdugo, A Messina, B Marchetti, N Iraci. Extracellular vesicles secreted by region-specific astrocytes ameliorate the mitochondrial function in a cellular model of Parkinson’s Disease. Adv Healthcare Mat, 2022 Oct;11(20):e2201203;

L Peruzzotti-Jametti and S Pluchino. Therapy with mesenchymal stem cell transplantation in multiple sclerosis is ready for prime time. MS Journal 2022; 9: 1328-1329;

CM Willis, AM Nicaise, G Krzak, B Ionescu, A D’Angelo, R Agarwal, S Pluchino. Signalling Properties of NSCs in Brain Physiology, Ageing and Inflammation. Exp Neurol 2022; 355: 114124;

AM Nicaise, A D’Angelo, CM Willis, RB Ionescu, G Krzak and S Pluchino. The Role of Neural Stem Cells in Regulating Scar Formation and Repair. Cell Tissue Res 2022 Mar;387(3):399-414;


LB Jarvis, D Rainbow, V Coppard, S Howlett, J Davies, H Kaur Mullay, J Heste, T Ashmore, A Van Den Bosch, J Grist, AJ Coles, H Mousa, S Pluchino, K Mahbubani, J Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, L Wicker, JL Jones. Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73. Comms Biol 2021; 4: 1186;

Smith JA, Nicaise AM, Ionescu RB, Hamel R, Peruzzotti-Jametti L, Pluchino S. Stem Cell Therapies for Progressive Multiple Sclerosis. Front Cell Dev Biol 2021 Jul 9; 9: 696434;

Peruzzotti-Jametti L, Willis CM, Hamel R, Krzak G, Pluchino S. Metabolic control of smouldering neuroinflammation. Front Immunol 2021 Jun 23; 12: 705920;

Peruzzotti-Jametti, JD Bernstock, CM Willis, G Manferrari, R Rogall, E Fernandez-Vizarra, JC Williamson, A Braga, A van den Bosch, T Leonardi, G Krzak, A Kittel, C Benincá, N Vicario, S Tan, C Bastos, I Bicci, N Iraci, JA Smith, B Peacock, KH Muller, PJ Lehner, EI Buzas, N Faria, M Zeviani, C Frezza, A Brisson, NJ Matheson, C Viscomi and S Pluchino. Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 2021 Apr 7;19(4):e3001166;

Islam Y, Leach AG, Smith J, Pluchino S, Coxon CR, Sivakumaran M, Downing J, Fatokun AA, Teixidò M, Ehtezazi T. Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles. Adv Sci (Weinh) 2021 Jun; 8(11): e2002085;

N Cunniffe, K Vuong, D Ainslie, D Baker, J Beveridge, S Bickley, P Camilleri. M Craner, D Fitzgerald, A de la Fuente, G Giovannoni, E Gray, L Hazlehurst, R Kapoor, R Kaur, D Kozlowski, D Mahad, B Neumann, L Peruzzotti-Jametti, S Pluchino, J Robertson, A Rothal, L Shellard, K Smith, A Wilkins, A Williams, A Coles. A systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2021; 92: 295–30;

Y Islam, P Ehtezazi, A Cashmore, E Marinsalda, AG Leach, CR Coxon, AA Fatokun, DW Sexton, I Khan, G Zouganelis, J Downing, S Pluchino, M Sivakumaran, M Teixido, T Ehtezazi.  The Inclusion of a Matrix Metalloproteinase-9 Responsive Sequence in Self-assembled Peptide-based Brain-Targeting Nanoparticles Improves the Efficiency of Nanoparticles Crossing the Blood-Brain Barrier at Elevated MMP-9 Levels. Journal of Pharmaceutical Sciences 2021; 110: 1349-1364;

S Pluchino and A Nicaise. NSCs: sentinel cells of the brain. Cell Stem Cell 2021; 28 (2): 177-179;


G Krzak, CM Willis, JA Smith, S Pluchino and L Peruzzotti-Jametti. Succinate receptor SUCNR1 (GPR91) - an emerging regulator of myeloid cell function in neuroinflammation. Trends Immunol 2020 Dec 2: S1471-4906(20)30262-3.


GM Sullivan, AK Knutsen, L Peruzzotti-Jametti, A Korotcov, JD Bernstock, A Bosomtwi, BJ Dardzinski, F Edenhofer, S Pluchino, RC Armstrong. Transplantation of induced neural stemcells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits. Acta Neuropathol Commun 2020 Jun 9;8(1):84;


N Cunniffe, K Vuong, D Ainslie, D Baker, J Beveridge, S Bickley, P Camilleri. M Craner, D Fitzgerald, A de la Fuente, G Giovannoni, E Gray, L Hazlehurst, R Kapoor, R Kaur, D Kozlowski, D Mahad, B Neumann, L Peruzzotti-Jametti, S Pluchino, J Robertson, A Rothal, L Shellard, K Smith, A Wilkins, A Williams, A Coles. A systematic approach to selectinglicensed drugs for repurposing in the treatment of progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2020 Nov 12: jnnp-2020-324286;


C Willis, A Nicaise, JA Smith, L Peruzzotti-Jametti and S Pluchino. Harnessing theNeural Stem Cell Secretome for Regenerative Neuroimmunology. Front Cell Neurosci 2020 Nov 5; 14:590960;


Y Islam, A Khalid, S Pluchino, M Sivakumaran, M Teixidò, A Leach, A Fatokun, J Downing, C Coxon, T Ehtezazi. Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity. Journal of Pharmaceutical Sciences 109 (10), 3134-3144;


A Braga, S Bandiera, J Verheyen, R Hamel, C Rutigliani, F Edenhofer, JA Smith and S Pluchino. Combination of in situ Lcn2 pRNA-RNAi nanotherapeutics and iNSC transplantation ameliorates experimental spinal cord injury in mice. Mol Ther 2020, 28 (12): 2677-2690;


Pluchino S, Smith JA, Peruzzotti-Jametti L. Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis. Trends Mol Med 2020 Oct;26(10):898-912;


Y Islam, AG Leach, JA Smith, S Pluchino, CR Coxon, M Sivakumaran, J Downing, AA Fatokun, M Teixidò, T Ehtezazi. Peptide based drug delivery systems to the Brain. Nano Express 1 (1), 012002;


Thiry L, Hamel R, Pluchino S, Durcan T, Stifani S. Characterization of Human iPSC-derivedSpinal Motor Neurons by Single-cell RNA Sequencing. Neuroscience 2020 Dec 1;450:57-70;


Pluchino S, Willis C. Intrinsic antiviral immunity drives neurodegeneration in Alzheimerdisease. J Clin Invest 2020 Apr 1;130(4):1622-1624;


Lilley E, Andrews MR, Bradbury EJ, Elliott H, Hawkins P, Ichiyama RM, Keeley J, Michael-Titus AT, Moon LDF, Pluchino S, Riddell J, Ryder K, Yip PK. Refining rodent models of spinalcord injury. Exp Neurol 2020 Jun;328:113273;


Marchetti B, Tirolo C, L'Episcopo F, Caniglia S, Testa N, Smith JA, Pluchino S, Serapide MF. Parkinson's disease, aging and adult neurogenesis: Wnt/β-catenin signalling as the key tounlock the mystery of endogenous brain repair. Aging Cell 2020 Mar;19(3):e13101;


Willis CM, Nicaise AM, Peruzzotti-Jametti L, Pluchino S. The neural stem cell secretomeand its role in brain repair. Brain Res 2020 Feb 15;1729:146615;


A Nicaise, C Willis, S Crocker and S Pluchino. Stem Cells of the Aging Brain. Front Aging Neurosci 2020 Aug 6;12:247;


Conejos-Sánchez I, Gallon E, Niño-Pariente A, Smith JA, De la Fuente AG, Di Canio L, Pluchino S, Franklin RJM, Vicent MJ. Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders. Nanoscale 2020, 12(11): 6285-6299.


C Falcone, M Santo, G Liuzzi, N Cannizzaro, C Grudina, E Valencic, L Peruzzotti-Jametti, S Pluchino and A Mallamaci. Foxg1 antagonizes neocortical stem cell progression to astrogenesis. Cereb Cortex 2019 Dec 17;29(12):4903-4918

G Volpe, JD Bernstock, L Peruzzotti-Jametti and S Pluchino. Modulation of host immune responses following non-hematopoietic stem cell transplants: Prospects for therapy in Progressive Multiple Sclerosis. J Neuroimmunol 2019 Jun 15;331:11-27 

*invited review article


S Pluchino and JA Smith. Explicating Exosomes: reclassifying the rising stars in intercellular communication. Cell 2019 Apr 4;177(2):225-227


JD Bernstock, L Peruzzotti-Jametti, N Vicario, D Ye, T Leonardi, KR Johnson, D Maric, Y Mou, FA Gessler, B Balzarotti, Y Lee, RJ Franklin, JM Hallenbeck, S Pluchino. Overexpression of the SUMO E2-conjugase Ubc9 enhances neural stem cell survival in experimental models of ischemia. EBiomedicine 2019 Apr;42:214-224


L Peruzzotti-Jametti and S Pluchino. Targeting mitochondrial metabolism in neuroinflammation: towards a therapy for progressive multiple sclerosis? Trends Mol Med 2018 Oct;24(10):838-855


F L’Episcopo, L Peruzzotti-Jametti, MF Serapide, C Tirolo, N Testa, B Balzarotti, S Caniglia, S Pluchino, B Marchetti. Neural stem cell transplantation in aged Parkinsonian mice promotes neurorestoration via promotion of astrocyte-induced Wnt/inflammatory cascade. Stem Cells 2018 2018 Aug;36(8):1179-1197


PP Amaral, T Leonardi, N Han1, E Viré, DK Gascoigne, R Arias-Carrasco, M Buscher, A Zhang, S Pluchino, V Maracaja-Coutinho, HI Nakaya, Martin Hemberg, R Shiekhattar, AJ Enright, T Kouzarides. Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci. Genome Biol 2018 Mar 15; 19(1): 32


JA Smith, A Braga, J Verheyen, S Basilico, C Alfaro-Cervello, L Peruzzotti-Jametti, F Haque, P Guo, S Pluchino. RNA nanotherapeutics for the amelioration of astroglial reactivity. Mol Ther Nucleic Acids 2018 Mar 2; 10: 103-121


E Mauri, A Sacchetti, N Vicario, L Peruzzotti-Jametti, F Rossi and S Pluchino. Hybrid hydrogel library as 3D neural stem cell culture systems. Biomater Sci 2018 Feb 27; 6(3): 501-510


L Peruzzotti-Jametti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza and S Pluchino. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell 2018 Mar 1; 22(3): 355-368

* Preview Commentary by Z Kokaia and O Lindvall. Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation. Cell Stem Cell 2018 Mar 1;22(3):283-285


Bernstock JD, Ye D, Smith JA, Lee YJ, Gessler FA, Yasgar A, Kouznetsova J, Jadhav A, Wang Z, Pluchino S, Zheng W, Simeonov A, Hallenbeck JM, Yang W. Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2. FASEB J 2018 Mar; 32(3): 1677-1691


F L'Episcopo, S Caniglia, C Tirolo, MF Serapide, N Testa, L Leggio, S Vivarelli, N Iraci, S Pluchino, B Marchetti. Microglia Polarization, Gene-Environment Interactions and Wnt/â-catenin Signalling: Emerging Roles of Glia-Neuron and Glia-Stem/Neuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Parkinsonian Brain. Front Aging Neurosci 2018 Feb 12; 10:12


M Donegà, E Giusto, T Leonardi, C Alfaro-Cervello and S Pluchino. Group I metabotropic glutamate receptor signalling regulates the release of BDNF and LIF by neural stem cells. Matters, DOI: 10.19185/matters.201801000002


JD Bernstock, W Yang, DG Ye, Y Shen, S Pluchino, Y Lee, JM Hallenbeck, W Paschen. SUMOylation in Brain Ischemia: Patterns, Targets, and Translational Implications. J Cereb Blood Flow Metab 2018 Jan;38(1):5-16


A Fuster-Matanzo, G Manferrari, B Marchetti and S Pluchino. Wnt3a promotes pro-angiogenic features in macrophages in vitro: implications for stroke pathology. Exp Biol Med (Maywood) 2018 Jan;243(1):22-2




Scolding NJ, Pasquini M, Reingold SC, Cohen JA on behalf of attendees at the International Conference on Cell-Based Therapies for Multiple Sclerosis. Cell-based therapeutic strategies for multiple sclerosis. Brain. 2017 Nov 1;140(11):2776-2796


JD Bernstock, D Ye, FA Gessler, L Peruzzotti-Jametti, MR Gilbert, Y Pommier, S Pluchino, I Nakano, JM Hallenbeck. Topotecan Decreases the Expression of Programmed Death-Ligand 1 in Glioblastoma; Implications for Immunotherapy. Matters(https://www.sciencematters.io/articles/201709000008/info)


Huang B, Jiang XC, Zhang TY, Hu YL, Tabata Y, Chen Z, Pluchino S, Gao JQ. Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia. Int J Pharm 2017 Aug 18; 531(1):90-100


N Iraci, E Gaude, T Leonardi, ASH Costa, C Cossetti, HK Saini, AJ Enright, C Frezza and S Pluchino. Extracellular vesicles are independent metabolic units delivering functional Asparaginase-like protein 1. Nat Chem Biol 2017 Sep;13(9):951-955

* News and Views by Lucas B Sullivan Extracellular Vesicles: Taking Metabolism on the Road. Nat Che Diol 2017 Aug 18;13(9):924-925


Bernstock JD, Ye D, Gessler FA, Lee YJ, Peruzzotti-Jametti L, Baumgarten P, Johnson KR, Maric D, Yang W, Kögel D, Pluchino S, Hallenbeck JM. Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming. Sci Rep 2017 Aug 7; 7(1):7425


JD Bernstock, L Peruzzotti-Jametti, D Ye, FA Gessler, Y Lee, JM Hallenbeck and S Pluchino. Neural Stem Cell transplantation in Ischemic Stroke: a Role for Preconditioning and Cellular Engineering. J Cereb Blood Flow Metab 2017 Jul; 37(7):2314-2319


E Giusto, M Donegà, A Dumitru, G Foschi, M Bianchi, A Russo, S Casalini, T Leonardi, F Biscarini, R Garcia and S Pluchino. Interfacing Polymers and Tissues: Quantitative Local Assessment of the Foreign Body Reaction of Mononuclear Phagocytes to Polymeric Materials. Adv Biosys doi: 10.1002/adbi.201700021


Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, Maji S, Monteleone F, Øverbye A, Panaretakis T, Patel T, Peinado H, Pluchino S, Principe S, Ronquist G, Royo F, Sahoo S, Spinelli C, Stensballe A, Théry C, van Herwijnen MJC, Wauben M, Welton JL, Zhao K, Mathivanan S. A novel community driven software for functional enrichment analysis of extracellular vesicles data. J Extracell Vesicles. 2017 May 26; 6(1):1321455


Ballini A, Scacco S, Coletti D, Pluchino S, Tatullo M. Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine. Stem Cells Int 2017; 2017: 3292810




Pluchino S, Peruzzotti-Jametti L. Interleukin-4 induced 1 (IL4I1) promotes central nervous system remyelination. Brain. 2016 Dec;139(Pt 12):3052-3054


S Pluchino, L Peruzzotti-Jametti, C Frezza. Astrocyte power fuels neurons during stroke. Swiss Med Wkly. 2016;146:w14374


D Drago, V Basso, E Gaude, G Volpe, L Peruzzotti-Jametti, A Bachi, G Musco, A Andolfo, C Frezza, A Mondino and S Pluchino. Metabolic determinants of the immune modulatory function of neural stem cells. J Neuroinflammation 2016 Sep 2;13(1):232


N Gagliano, G Celesti, L Tacchini, S Pluchino, M Rasile, V Valerio, L Laghi, V Conte, P Procacci. Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma cells: characterization in a 3D-cell culture model. World J Gastroent 2016 May 14;22(18):4466-83


S Stewart, F Gessler, S Pluchino and K Moreau. Inside out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles. Matters (https://www.sciencematters.io/articles/201602000015)


B Ossola, C Zhao, M Goedert, A Compston, S Pluchino, RJM Franklin, MG Spillantini. Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation. GLIA. 2016 Mar;64(3):457-71


N Iraci, T Leonardi, F Gessler, B Vega and S Pluchino. Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles. Int J Mol Sci. 2016 Feb 6;17(2) *invited review article


JD Bernstock, Y Lee, L Peruzzotti-Jametti, N Southall, KR Johnson, D Maric, G Volpe, J Kouznetsova, W Zheng, S Pluchino, JM Hallenbeck. A Novel Quantitative High-throughput Screen Identifies Drugs that both Activate SUMO-conjugation via the Inhibition of MicroRNAs 182 and 183 and Facilitate Neuroprotection in a Model of Oxygen and Glucose Deprivation. J Cereb Blood Flow Metab. 2016 Feb;36(2):426-41




T Lener et al.  Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. Journal of Extracellular Vesicles 2015, 4: 30087


A Fuster-Matanzo, F Gessler, T Leonardi, N Iraci and S Pluchino. Acellular Approaches for Regenerative Medicine: on the Verge of Clinical Trials with Extracellular Membrane Vesicles? Stem Cell Res Ther 2015 Dec 2;6:227 *invited review article


S Tambalo, L Peruzzotti-Jametti, R Rigolio, S Fiorini, P Bontempi, G Mallucci, A Sbarbati, P Marmiroli, G Cavaletti, S Pluchino, P Marzola. Functional magnetic resonance imaging reveal brain cortex remodelling in a rat model of chronic multiple sclerosis. J Neurosci 2015 July 8;35(27): 10088 –10100


Smith JA, Leonardi T, Huang B, Iraci N, Vega B, Pluchino S. Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases. Biogerontology. 2015 Apr;16(2):147-85


Mallucci G, Peruzzotti-Jametti L, Bernstock JD, Pluchino S. The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis. Prog Neurobiol 2015 Apr;127-128C:1-22


GM Tannahill, N Iraci, E Gaude, C Frezza and S Pluchino. Metabolic reprogramming of mononuclear phagocytes and progressive multiple sclerosis. Front Immunol 2015 Mar 11;6:106




Giusto E, Donegà M, Cossetti C and Pluchino S. Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. Exp Neurol 2014 Oct;260C:19-32


C Cossetti, N Iraci, TR Mercer, T Leonardi, E Alpi, D Drago, C Alfaro-Cervello, H Saini, M Davis, J Schaeffer, W Muller, JM Garcia-Verdugo, S Mathivanan, A Bachi, A Enright, JS Mattick, S Pluchino. Extracellular vesicles from neural stem cells transfer IFN- via Ifngr1 to activate Stat1 signalling in target cells. Mol Cell 2014 Oct 23;56(2):193-204


DM Hermann, L Peruzzotti-Jametti, J Schlechter, JD Bernstock, TR Doeppner, S Pluchino. Neural precursor cells in the ischemic brain - integration, cellular crosstalk and consequences for stroke recovery. Front Cell Neurosci 2014 Sep 16;8:291


L Peruzzotti-Jametti, M Donegá, E Giusto, G Mallucci, B Marchetti, S Pluchino. The role of immune system in central nervous system plasticity after acute injuries. Neuroscience 2014 Dec 26;283:210-221


M Donegà, E Giusto, C Cossetti, J Schaeffer and S Pluchino. Systemic injection of neural stem/progenitor cells in mice with chronic EAE.  J Vis Exp 2014 Apr 15;(86)


F L’Episcopo, C Tirolo, N Testa, S Caniglia, MC Morale, MF Serapide, S Pluchino, B Marchetti. Wnt/â-catenin signalling is required to rescue midbrain dopaminergic progenitors and restore nigrostriatal plasticity in ageing mouse model of Parkinson’s disease.  Stem Cells 2014 Aug;32(8):2147-63 


Cerri F, Salvatore L, Memon D, Martinelli Boneschi F, Madaghiele M, Brambilla P, Del Carro U, Taveggia C, Riva N, Trimarco A, Lopez ID, Comi G, Pluchino S, Martino G, Sannino A, Quattrini A. Peripheral nerve morphogenesis induced by scaffold micropatterning. Biomaterials 2014; 35: 4035-45 


F L’Episcopo, C Tirolo, S Caniglia, N Testa, MC Morale, MF Serapide, S Pluchino, B Marchetti. Targeting Wnt signaling at the neuroimmune interface in dopaminergic neuroreprotection/repair in Parkinson’s disease. J Mol Cell Biol 2014; 6: 13-26




AF Hill, DM Pegtel, U Lambertz, T Leonardi, L O’Driscoll, S Pluchino, D Ter-Ovanesyan, ENM Nolte-‘t Hoen. ISEV Position Paper: Extracellular Vesicle RNA analysis and bioinformatics. J Extracell Vesicles 2013 Dec 23;2


S Pluchino and L Peruzzotti-Jametti. Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons. Brain 2013, 136: 3525-3527


D Drago, C Cossetti, N Iraci, E Gaude, G Musco, A Bachi and S Pluchino. The stem cell secretome and its role in brain repair. BIOCHIMIE. 2013 Dec;95(12):2271-85


Pluchino S and Cossetti C. How stem cells speak with host immune cells in inflammatory brain diseases. GLIA 2013 Sep;61(9):1379-401


Marchetti B, L’Episcopo F, Morale MC, Tirolo C, Testa N, Caniglia S, Serapide MF and Pluchino S. Uncovering Novel Actors in Astrocyte-Neuron Crosstalk in Parkinson’s Disease: the Wnt/â-Catenin Signaling Cascade as Common Final Pathway for Neuroprotection and Self-Repair. Eur J Neurosci 2013 May; 37(10):1550-63


L'episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Impagnatiello F, Pluchino S, Marchetti B. Aging-Induced Nrf2-ARE Pathway Disruption in the Subventricular Zone Drives Neurogenic Impairment in Parkinsonian Mice via PI3K-Wnt/â-Catenin Dysregulation. J Neurosci 2013 Jan 23;33(4):1462-148


Marchetti B, Pluchino S. Wnt your brain be inflamed? Yes, it Wnt! Trends Mol Med 2013 Mar;19(3):144-56




Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012 Dec;10(12):e1001450


Cossetti C, Alfaro-Cervello C, Donegà M, Tyzack G, Pluchino S. New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies. Cell Tissue Res. 2012 Jul;349(1):321-9


Herz J, Reitmeir R, Hagen SI, Reinboth BS, Guo Z, Zechariah A, ElAli A, Doeppner TR, Bacigaluppi M, Pluchino S, Kilic U, Kilic E, Hermann DM. Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions. Neurobiol Dis. 2012 Mar;45(3):1077-85


L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Deleidi M, Serapide MF, Pluchino S, Marchetti B. Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/â-catenin signaling pathways: functional consequences for neuroprotection and repair. J Neurosci. 2012 Feb 8;32(6):2062-85


Cusimano M, Biziato D, Brambilla E, Donegà M, Alfaro-Cervello C, Snider S, Salani G, Pucci F, Comi G, Garcia-Verdugo JM, De Palma M, Martino G, Pluchino S. Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord. Brain. 2012 Feb;135(Pt 2):447-60


Cossetti C, Smith JA, Iraci N, Leonardi T, Alfaro-Cervello C, Pluchino S. Extracellular membrane vesicles and immune regulation in the brain. Front Physiol. 2012;3:117




Pluchino S, Alfaro-Cervello C. Cyclooxygenase (COX)-1 takes control of adult hippocampal neurogenesis. Cell Cycle. 2011 Oct 1;10(19):3229


Martino G, Pluchino S, Bonfanti L, Schwartz M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol Rev. 2011 Oct;91(4):1281-304


L'episcopo F, Serapide MF, Tirolo C, Testa N, Caniglia S, Morale MC, Pluchino S, Marchetti B. A Wnt1 regulated Frizzled-1/â-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection. Mol Neurodegener. 2011 Jul 13;6:49


Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV. Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis. Cell Stem Cell. 2011 May 6;8(5):538-51


L'Episcopo F, Tirolo C, Testa N, Caniglia S, Morale MC, Cossetti C, D'Adamo P, Zardini E, Andreoni L, Ihekwaba AE, Serra PA, Franciotta D, Martino G, Pluchino S, Marchetti B. Reactive astrocytes and Wnt/â-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease. Neurobiol Dis. 2011 Feb;41(2):508-27


Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S, Gassmann M, Hermann DM. Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Brain. 2011 Jan;134(Pt 1):84-99




Pluchino S, Cusimano M, Bacigaluppi M, Martino G. Remodelling the injured CNS through the establishment of atypical ectopic perivascular neural stem cell niches. Arch Ital Biol. 2010 Jun;148(2):173-83 


Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V, Bosi E, Martino G, Bonifacio E, Doglioni C, Piemonti L. Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice. PLoS One. 2010 Apr 27;5(4):e10357


Freedman MS, Bar-Or A, Atkins HL, Karussis D, Frassoni F, Lazarus H, Scolding N, Slavin S, Le Blanc K, Uccelli A; MSCT Study Group. The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group. Mult Scler. 2010 Apr;16(4):503-10




Gagliano N, Costa F, Cossetti C, Pettinari L, Bassi R, Chiriva-Internati M, Cobos E, Gioia M, Pluchino S. Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model. Oncol Rep. 2009 Dec;22(6):1349-56


Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, 't Hart B, Vescovi A, Martino G. Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates. Ann Neurol. 2009 Sep;66(3):343-54


Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ, Comi G, Martino G, Hermann DM. Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain. 2009 Aug;132(Pt 8):2239-51


Shechter R, London A, Varol C, Raposo C, Cusimano M, Yovel G, Rolls A, Mack M, Pluchino S, Martino G, Jung S, Schwartz M. Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med. 2009 Jul;6(7):e1000113


Pluchino S, Zanotti L, Brambilla E, Rovere-Querini P, Capobianco A, Alfaro-Cervello C, Salani G, Cossetti C, Borsellino G, Battistini L, Ponzoni M, Doglioni C, Garcia-Verdugo JM, Comi G, Manfredi AA, Martino G. Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One. 2009 Jun 19;4(6):e5959


Pluchino S, Zanotti L, Brini E, Ferrari S, Martino G. Regeneration and repair in multiple sclerosis: the role of cell transplantation. Neurosci Lett. 2009 Jun 12;456(3):101-6 




Pluchino S, Muzio L, Imitola J, Deleidi M, Alfaro-Cervello C, Salani G, Porcheri C, Brambilla E, Cavasinni F, Bergamaschi A, Garcia-Verdugo JM, Comi G, Khoury SJ, Martino G. Persistent inflammation alters the function of the endogenous brain stem cell compartment. Brain. 2008 Oct;131(Pt 10):2564-78 


Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Esposito M, Stornaiuolo A, Comi G, Pluchino S, Mavilio F, Martino G, Furlan R. IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther. 2008 Apr;15(7):504-15


Pluchino S, Martino G. Neural stem cell-mediated immunomodulation: repairing the haemorrhagic brain. Brain. 2008 Mar;131(Pt 3):604-5 


Pluchino S, Martino G. The therapeutic plasticity of neural stem/precursor cells in multiple sclerosis. J Neurol Sci. 2008 Feb 15;265(1-2):105-10 


Bacigaluppi M, Pluchino S, Martino G, Kilic E, Hermann DM. Neural stem/precursor cells for the treatment of ischemic stroke. J Neurol Sci. 2008 Feb 15;265(1-2):73-7 


Serra PA, Pluchino S, Marchetti B, Desole MS, Miele E. The MPTP mouse model: cues on DA release and neural stem cell restorative role. Parkinsonism Relat Disord. 2008;14 Suppl 2:S189-93. doi: 10.1016/j.parkreldis.2008.04.029




Politi LS, Bacigaluppi M, Brambilla E, Cadioli M, Falini A, Comi G, Scotti G, Martino G, Pluchino S. Magnetic-resonance-based tracking and quantification of intravenously injected neural stem cell accumulation in the brains of mice with experimental multiple sclerosis. Stem Cells. 2007 Oct;25(10):2583-92 


Martino G, Pluchino S. Neural stem cells: guardians of the brain. Nat Cell Biol. 2007 Sep;9(9):1031-4 




Ziv Y, Avidan H, Pluchino S, Martino G, Schwartz M. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13174-9


Martino G, Pluchino S. The therapeutic potential of neural stem cells. Nat Rev Neurosci. 2006 May;7(5):395-406 


Amadio S, Pluchino S, Brini E, Morana P, Guerriero R, Martinelli Boneschi F, Comi G, Zaratin P, Muzio V, del Carro U. Motor evoked potentials in a mouse model of chronic multiple sclerosis. Muscle Nerve. 2006 Feb;33(2):265-73 


Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci. 2006 Jan;31(1):149-60 




Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature. 2005 Jul 14;436(7048):266-71 


Pluchino S, Martino G. The therapeutic use of stem cells for myelin repair in autoimmune demyelinating disorders. J Neurol Sci. 2005 Jun 15;233(1-2):117-9 


Pluchino S, Zanotti L, Deleidi M, Martino G. Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev. 2005 Apr;48(2):211-9 


Pluchino S, Bacigaluppi M, Bucello S, Butti E, Deleidi M, Zanotti L, Martino G, Furlan R. Gene and stem cell therapy for autoimmune demyelination. Ernst Schering Res Found Workshop. 2005;(53):133-46




Furlan R, Butti E, Pluchino S, Martino G. Gene therapy for autoimmune diseases. Curr Opin Mol Ther. 2004 Oct;6(5):525-36


Pluchino S, Furlan R, Martino G. Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies. Curr Opin Neurol. 2004 Jun;17(3):247-55




Pluchino S, Zanotti L, Martino G. Antibodies and myelination: facts and misacts. Neurol Sci. 2003 Oct;24 Suppl 4:S231-3


Furlan R, Pluchino S, Martino G. The therapeutic use of gene therapy in inflammatory demyelinating diseases of the central nervous system. Curr Opin Neurol. 2003 Jun;16(3):385-92 


Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003 Apr 17;422(6933):688-94

*News and Views by L Steinman Collateral damage repaired. Nature. 2003 Apr 17;422(6933):671-2


Furlan R, Brambilla E, Sanvito F, Roccatagliata L, Olivieri S, Bergami A, Pluchino S, Uccelli A, Comi G, Martino G. Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain. 2003 Feb;126(Pt 2):285-91


Furlan R, Pluchino S, Martino G. Gene therapy-mediated modulation of immune processes in the central nervous system. Curr Pharm Des. 2003;9(24):2002-8


Furlan R, Pluchino S, Marconi PC, Martino G. Cytokine gene delivery into the central nervous system using intrathecally injected nonreplicative viral vectors. Methods Mol Biol. 2003;215:279-89




Annunziata P, Pluchino S, Martino T, Guazzi G. High levels of cerebrospinal fluid IgM binding to myelin basic protein are associated with early benign course in multiple sclerosis. J Neuroimmunol. 1997 Jul;77(1):128-33